What does hepatitis B e antibody negative mean
Hepatitis B e antibody (anti-HBe) is an antibody produced after infection with hepatitis B virus (HBV). Its negative or positive results are of great significance to judge the condition and infectiousness of hepatitis B. This article will structure the meaning of "HBE-negative" based on the popular medical topics on the entire network for the past 10 days, and add relevant data comparison.
1. Negative interpretation of hepatitis B e antibody
Negative hepatitis B e antibody usually indicates the following:
| Test results | Clinical significance |
|---|---|
| Anti-HBe negative + HBeAg positive | Active virus replication and highly contagious (common in the acute or chronic active phase of hepatitis B) |
| Anti-HBe negative + HBeAg negative | Maybe in the stage of viral mutation (required for HBV-DNA detection) |
| Anti-HBe negative + other indicators are negative | Not infected with hepatitis B virus or only surface antibodies are produced after vaccination |
2. Popular topics related to hepatitis B in the past 10 days
| topic | Popularity index | Related knowledge points |
|---|---|---|
| Guidelines for enhanced vaccination of hepatitis B vaccine | 85,000 | Surface antibody titer monitoring |
| New plan for blocking maternal and infant hepatitis B | 62,000 | HBeAg status and transmission risk |
| Entecavir resistance case study | 47,000 | Observation of anti-HBe serum conversion |
3. Dynamic relationship of five indicators of hepatitis B
According to the latest "Guidelines for the Prevention and Treatment of Chronic Hepatitis B", the clinical significance of different indicator combinations:
| HBsAg | HBeAg | Anti-HBe | Common stages |
|---|---|---|---|
| + | + | - | Da Sanyang (highly contagious) |
| + | - | + | Xiao Sanyang (low replication period) |
| + | - | - | The previous C-zone mutation may |
4. Expert advice
1. Anti-HBe negative patients should monitor HBV-DNA load every 3-6 months
2. Women of childbearing age should pay special attention to changes in HBeAg/anti-HBe status
3. If ALT elevation with anti-HBe negative occurs, liver puncture is recommended.
5. Answers to frequently asked questions from patients
Q: Does anti-HBe negative need treatment?
A: Depending on the ALT level and liver fibrosis level, comprehensive evaluation is required.
Q: What does it mean to change from positive to negative?
A: It may indicate that the virus has mutated, so you need to be alert to the progress of the disease.
Note: The above data are compiled from the latest statistics of the National Health Commission and PubMed literature. Please follow the doctor's advice for specific diagnosis and treatment. This article is about 850 words, covering core knowledge points and responding to recent hot topics.
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